Horizon Pharma plc Announces Second-Quarter 2016 Financial Results

by | Aug 8, 2016 | Globe Newswire

— Second-Quarter 2016 Record Net Sales of $257.4 Million, Up 49 Percent —

— Second-Quarter 2016 GAAP Net Income of $15.0 Million; Adjusted EBITDA of $121.1 Million —

— Confirms Full-Year 2016 Net Sales Guidance of $1.025 to $1.050 Billion and Full-Year 2016 Adjusted EBITDA Guidance of $495 to $510 Million —

DUBLIN, Ireland, Aug. 08, 2016 (GLOBE NEWSWIRE) — Horizon Pharma plc (NASDAQ:HZNP), a biopharmaceutical company focused on improving patients’ lives by identifying, developing, acquiring and commercializing differentiated and accessible medicines that address unmet medical needs, announced its second-quarter 2016 financial results today and confirmed its full-year 2016 net sales and adjusted EBITDA guidance.

“We exceeded our expectations for the second quarter with another quarter of record net sales and remain on track to meet our objectives for the full year,” said Timothy P. Walbert, chairman, president and chief executive officer, Horizon Pharma plc.  “We continued to execute across all levels of the organization, generating new patient and prescription growth and advancing our pipeline of orphan medicines, including the completion of enrollment in our Phase 3 clinical trial for ACTIMMUNE in Friedreich’s ataxia and the submission of our supplemental new drug application for RAVICTI.”

Financial Highlights

(in millions except for per share amounts and percentages)   Q2 16   Q2 15   %
Change		   YTD 16   YTD 15   %
Change
                         
Net sales   $   257.4     $   172.8       49     $   462.1     $   286.0     62
Net income (loss)       15.0         31.8       (53 )       (30.4 )       12.3      NM
Non-GAAP net income (1)       101.1         61.9       63         156.5         86.4     81
Adjusted EBITDA       121.1         76.1       59         193.1         108.5     78
                         
Earnings (loss) per share – diluted       0.09         0.20       (55 )       (0.19 )       0.08      NM
Non-GAAP earnings per share – diluted (1)       0.62         0.39       59         0.96         0.60     60
 
(1) Horizon Pharma is modifying the method of calculating its non-GAAP income tax expense to align with guidance issued by the U.S. Securities and Exchange Commission (SEC) on May 17, 2016.  The table above reflects the Company’s prior method of calculating its non-GAAP income tax expense.  Please see the income tax rate discussion in the section titled, “Second-Quarter 2016 Financial Results,” to understand the Company’s new method of calculating its non-GAAP income tax expense as well as a comparison of its non-GAAP tax rate, non-GAAP net income and non-GAAP diluted earnings per share under the new and prior methodologies for 2015 and 2016.  This modification has no impact on the amount of cash taxes paid, the Company’s operating cash flows or its full-year 2016 guidance.
 

Company Highlights

  • Second-quarter 2016 year-over-year sales growth of 49 percent was driven by strong execution across each of the Company’s business units:  Orphan, Rheumatology and Primary Care.  Medicines for rare diseases, which include RAVICTI®, ACTIMMUNE®, KRYSTEXXA® and BUPHENYL®, represented 36 percent of total net sales in the second quarter of 2016, an increase from 28 percent of total net sales in the second quarter of 2015.
  • Second-quarter 2016 net income was $15.0 million.  Second-quarter 2016 adjusted EBITDA was $121.1 million. 
  • On August 2, 2016, the Company announced it had secured covered status for DUEXIS® and VIMOVO® with CVS/Caremark.  The Company was informed that beginning January 1, 2017, DUEXIS and VIMOVO will be removed from the CVS/Caremark exclusion list.  In addition, Horizon continues discussions and negotiations with other pharmacy benefit managers and payers with the goal of further increasing patient access to its clinically relevant primary care medicines in 2017.
  • On June 29, 2016, the Company submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) for RAVICTI to expand its age range of use for chronic management of urea cycle disorders (UCDs) in adult and pediatric patients from two years of age and older to two months of age and older. 
  • On May 18, 2016, the Company entered into an agreement to acquire the worldwide rights to interferon gamma-1b, known as ACTIMMUNE in the United States, and expects to close the transaction by year-end 2016, subject to the satisfaction of closing conditions.

Second-Quarter Business Unit Net Sales Results

    (in millions except for percentages)   Q2 16   Q2 15   %
Change		   YTD 16   YTD 15   %
Change
    Orphan   $   73.5     $   48.7       51     $   139.8     $   73.5       90  
      RAVICTI®(1)     39.4         19.0       107         76.4         19.0       302  
      ACTIMMUNE®       30.0         25.8       16         55.6         50.6       10  
      BUPHENYL®(1)       4.1         3.9       5         7.8         3.9       102  
    Rheumatology       33.2         10.7       211         60.6         18.9       220  
      KRYSTEXXA®(2)       19.9         –        NM         36.0         –        NM  
      RAYOS®       12.1         10.3       18         22.7         17.5       29  
      LODOTRA®       1.2         0.4       218         1.9         1.4       34  
    Primary Care       150.7         113.4       33         261.7         193.5       35  
      PENNSAID® 2%       72.7         29.4       147         127.6         47.7       168  
      DUEXIS®       45.5         44.2       3         75.2         73.1       3  
      VIMOVO®       31.4         39.8       (21 )       56.9         72.8       (22 )
      MIGERGOT®(2)       1.1         –        NM         2.0         –        NM  
    Total net sales   $   257.4     $   172.8       49     $   462.1     $   286.0       62  
                             
    (1) RAVICTI and BUPHENYL were acquired on May 7, 2015. 
    (2) KRYSTEXXA and MIGERGOT were acquired on January 13, 2016. 
     
  • Orphan Business Unit:  The orphan commercial organization continues to add new patients to treatment with RAVICTI and ACTIMMUNE.  RAVICTI sales in the second quarter of 2016 were $39.4 million, an increase of 107 percent compared to the second quarter of 2015 and 6 percent sequentially compared to the first quarter of 2016.  ACTIMMUNE sales in the second quarter of 2016 were $30.0 million, an increase of 16 percent compared to the second quarter of 2015 and 18 percent sequentially compared to the first quarter of 2016.

    Regarding its clinical development pipeline for orphan diseases, the Company submitted a sNDA to the U.S. FDA for RAVICTI to expand its age range of use for chronic management of UCDs from two years of age and older to two months of age and older.  If approved, physicians could use RAVICTI instead of BUPHENYL in patients two months to two years of age. The Company completed enrollment in the Safety, Tolerability and Efficacy of ACTIMMUNE Dose Escalation in FA (STEADFAST) Phase 3 clinical trial for ACTIMMUNE on May 5, 2016.  With an estimated 3,700 patients in the United States with FA, the Company believes an indication for ACTIMMUNE in FA, if approved, could represent a $500 million to $1 billion peak annual net sales opportunity.  In the Phase 1 dosing trial evaluating ACTIMMUNE as a combination therapy for certain cancers, the first six-patient cohort was completed in May and the second six-patient cohort is now enrolling.

    On May 18, 2016, the Company entered into an agreement to acquire the worldwide rights to interferon gamma-1b, known as ACTIMMUNE in the United States.  The transaction is expected to close by year-end 2016.  Horizon Pharma currently owns the rights to interferon gamma-1b in the United States, Canada and Japan and the acquisition will expand rights worldwide.  Interferon gamma-1b is currently sold in an estimated 30 countries outside the U.S.  Obtaining worldwide rights for interferon gamma-1b will solidify continued investment in the medicine, and pending the outcome of clinical studies investigating it in FA and advanced solid tumors such as kidney and bladder cancer, strengthens the Company’s ability to expand its potential global use.

  • Rheumatology Business Unit:  KRYSTEXXA sales in the second quarter of 2016 were $19.9 million, following the expansion of its commercial organization after the acquisition of Crealta in January 2016.  The Company is continuing to capitalize on this expansion effort as well as invest in education and outreach with practicing physicians to share the robust safety and efficacy data from the KRYSTEXXA pivotal trials.  RAYOS® sales in the second quarter of 2016 were $12.1 million, an increase of 18 percent compared to the second quarter of 2015.

    The Company has submitted several abstracts of KRYSTEXXA Phase 3 trial data analyses to the American College of Rheumatology (ACR) annual meeting in November.  In addition, data from the Tolerization Reduces Intolerance to Pegloticase and Prolongs the Urate Lowering Effect (TRIPLE) trial will also be submitted to the ACR meeting.  The TRIPLE trial is evaluating safety and efficacy related to KRYSTEXXA immunogenicity.  

  • Primary Care Business Unit:  PENNSAID® 2% sales in the second quarter of 2016 were $72.7 million, an increase of 147 percent compared to the second quarter of 2015.  DUEXIS and VIMOVO sales in the second quarter of 2016 were $45.5 million and $31.4 million, respectively.  Total prescriptions for the primary care business unit increased approximately 22 percent compared to the second quarter of 2015, driven primarily by strong performance of PENNSAID 2%. 

Second-Quarter 2016 Financial Results
Note:  For additional detail and reconciliation of non-GAAP financial measures to the most directly comparable GAAP financial measures, please refer to the tables at the end of this release.

  • Gross Profit:  Under U.S. generally accepted accounting principles (GAAP) in the second quarter of 2016, the gross profit ratio was 68.5 percent compared to 64.2 percent in the second quarter of 2015.  The non-GAAP gross profit ratio in the second quarter of 2016 was 92.0 percent compared to 91.1 percent in the second quarter of 2015.
     
  • Operating Expenses:  On a GAAP basis in the second quarter of 2016, total operating expenses were 56.3 percent of sales.  Research & development (R&D) expenses were 4.4 percent of sales, sales & marketing (S&M) expenses were 30.9 percent of sales and general & administrative (G&A) expenses were 21.0 percent of sales.  Non-GAAP total operating expenses in the second quarter of 2016 were 44.9 percent of sales.  Non-GAAP R&D expenses were 3.3 percent of sales, non-GAAP S&M expenses were 28.1 percent of sales and non-GAAP G&A expenses were 13.5 percent of sales.
     
  • Income Tax Rate:  Horizon Pharma is modifying the method of calculating its non-GAAP income tax expense to align with guidance issued by the SEC on May 17, 2016.  The new methodology, which the Company will begin using exclusively in the third quarter, calculates the income tax component of non-GAAP net income for each period by adjusting the GAAP income tax expense (benefit) for the estimated tax impact of each non-GAAP adjustment based on the statutory tax rate of the applicable jurisdiction for each non-GAAP adjustment.  This new methodology does not reflect any use of net operating loss carryforwards that the Company potentially may have been able to use if its actual earnings for these periods had been the non-GAAP net income.  Importantly, this change has no impact on the amount of cash taxes paid, operating cash flows or full-year guidance for net sales or adjusted EBITDA.  Previously, the Company had calculated the income tax component of non-GAAP net income by using the estimated cash taxes that it expected to pay for the period.  The tables below provide the GAAP to non-GAAP income tax rate reconciliation using both the new and prior methodology along with the resulting non-GAAP net income and non-GAAP diluted earnings per share under each method.  A full reconciliation for the first and second quarters of 2016 and all of 2015 are at the end of this release and posted to the investor relations section of the Horizon Pharma website.
 
 GAAP to Non-GAAP Tax Rate Reconciliation (Unaudited) for Q2 2016, Q2 2015 and
 Year-to-Date 2016 and 2015
 
  Q2 2016
  Pre-tax Net
Income		  Income Tax
Expense (Benefit) 		Tax Rate Net Income Diluted Earnings
Per Share
As reported – GAAP $   12.2   $   (2.8 )   (22.5 )% $   15.0   $   0.09  
Non-GAAP adjustments     94.3       18.0         76.3    
Non-GAAP – new methodology $   106.5   $   15.2     14.4 % $   91.3   $   0.56  
           
As reported – GAAP $   12.2   $   (2.8 )   (22.5 )% $   15.0   $   0.09  
Non-GAAP adjustments     94.3       8.2         86.1    
Non-GAAP – prior methodology $   106.5   $   5.4     5.1 % $   101.1   $   0.62  

  Q2 2015
  Pre-tax Net
Income (Loss)		  Income Tax
Expense (Benefit) 		Tax Rate Net Income
(Loss)		 Diluted Earnings
Per Share
As reported – GAAP $   (128.9 ) $   (160.7 )   124.7 % $   31.8   $   0.20  
Non-GAAP adjustments     191.2       59.0         132.2    
Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
Non-GAAP – new methodology $   62.3   $   3.4     5.6 % $   58.9   $   0.37  
           
As reported – GAAP $   (128.9 ) $   (160.7 )   124.7 % $   31.8   $   0.20  
Non-GAAP adjustments     191.2       56.0         135.2    
Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
Non-GAAP – prior methodology $   62.3   $   0.4     0.7 % $   61.9   $   0.39  

  Q2 2016 YTD
  Pre-tax Net
Income (Loss)		  Income Tax
Expense (Benefit) 		Tax Rate Net Income
(Loss)		 Diluted Earnings
(Loss) Per Share
As reported – GAAP $   (34.6 ) $   (4.2 )   12.1 % $   (30.4 ) $   (0.19 )
Non-GAAP adjustments     198.3       35.3         163.0    
Non-GAAP – new methodology $   163.7   $   31.1     19.0 % $   132.6   $   0.81  
           
As reported – GAAP $   (34.6 ) $   (4.2 )   12.1 % $   (30.4 ) $   (0.19 )
Non-GAAP adjustments     198.3       11.4         186.9    
Non-GAAP – prior methodology $   163.7   $   7.2     4.4 % $   156.5   $   0.96  

  Q2 2015 YTD
  Pre-tax Net
Income (Loss)		  Income Tax
Expense (Benefit) 		Tax Rate Net Income
(Loss)		 Diluted Earnings
Per Share
As reported – GAAP $   (146.5 ) $   (158.8 )   108.4 % $   12.3   $   0.08  
Non-GAAP adjustments     233.6       59.2         174.4    
Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
Non-GAAP – new methodology $   87.1   $   5.5     6.4 % $   81.6   $   0.56  
           
As reported – GAAP $   (146.5 ) $   (158.8 )   108.4 % $   12.3   $   0.08  
Non-GAAP adjustments     233.6       54.4         179.2    
Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
Non-GAAP – prior methodology $   87.1   $   0.7     0.8 % $   86.4   $   0.60  
                               

  On a GAAP basis in the second quarter of 2016, the tax rate was (22.5) percent and the non-GAAP tax rate using the new method for calculating non-GAAP income taxes was 14.4 percent.  For comparison purposes only during this transition period, under the prior methodology, the cash tax rate was 5.1 percent, which was in line with the Company’s previous full-year cash tax rate guidance of low single digits. 
  • Net Income: On a GAAP basis in the second quarter of 2016, net income was $15.0 million and non-GAAP net income using the tax rate of 14.4 percent was $91.3 million.  For comparison purposes only during this transition period, non-GAAP net income using the cash tax rate of 5.1 percent was $101.1 million.  On a GAAP basis in the second quarter of 2015, net income was $31.8 million and non-GAAP net income using the non-GAAP tax rate of 5.6 percent was $58.9 million.  For comparison purposes only during this transition period, non-GAAP net income using the cash tax rate of 0.7 percent was $61.9 million.  (Please refer to tax rate reconciliation tables in this release and on the Horizon Pharma website).  
     
  • EBITDA: On an unadjusted basis in the second quarter of 2016, EBITDA was $101.9 million, or 39.6 percent of sales.  Adjusted EBITDA in the second quarter of 2016 was $121.1 million, or 47.0 percent of sales, compared to $76.1 million, or 44.0 percent of sales in the second quarter of 2015.
     
  • Earnings per Share: On a GAAP basis in the second quarter of 2016, diluted earnings per share was $0.09 and non-GAAP diluted earnings per share using the non-GAAP tax rate of 14.4 percent was $0.56.  For comparison purposes only during this transition period, non-GAAP diluted earnings per share using the cash tax rate of 5.1 percent was $0.62.  Weighted average shares outstanding used for calculating diluted earnings per share in the second quarter of 2016 were 163.9 million.  On a GAAP basis in the second quarter of 2015, diluted earnings per share was $0.20 and non-GAAP diluted earnings per share using the non-GAAP tax rate of 5.6 percent was $0.37.  For comparison purposes only during this transition period, non-GAAP diluted earnings per share using the cash tax rate of 0.7 percent was $0.39 as previously reported.  (Please refer to tax rate reconciliation tables in this release and on the Horizon Pharma website).

Cash Flow Statement and Balance Sheet Highlights

  • On a GAAP basis in the second quarter of 2016, operating cash flow was $47.3 million.  Non-GAAP operating cash flow was $58.2 million in the second quarter of 2016.  On a GAAP basis, the first half of 2016 operating cash flow was $101.5 million compared to the first half of 2015 operating cash flow of ($29.2) million.  On a non-GAAP basis, the first half of 2016 operating cash flow was $126.1 million compared to the first half of 2015 operating cash flow of $66.4 million.
  • The Company had cash and cash equivalents of $424.5 million as of June 30, 2016.   
  • Total principal amount of debt outstanding was $1.271 billion as of June 30, 2016, which was composed of $396 million in senior secured term loans due 2021, $475 million in 6.625 percent senior notes due 2023 and $400 million of 2.5 percent exchangeable senior notes due 2022. Net debt in the second quarter was $846.5 million.
  • As of June 30, 2016, the Company had a total debt to last 12 months (LTM) adjusted EBITDA leverage ratio of 2.8 and a net debt to LTM adjusted EBITDA leverage ratio of 1.9.

Conference Call

At 8 a.m. EDT / 1 p.m. IST today, the Company will host a live conference call and webcast to review its financial and operating results and provide a general business update.

U.S. Dial-In Number: +1 888.338.8373
International Dial-In Number: +1 973.872.3000
Passcode: 43465144

The live webcast and a replay may be accessed by visiting Horizon’s website at http://ir.horizon-pharma.com.  Please connect to the Company’s website at least 15 minutes prior to the live webcast to ensure adequate time for any software download that may be needed to access the webcast. 

A replay of the conference call will be available approximately two hours after the call and accessible through one of the following telephone numbers, using the passcode below:

Replay U.S. Dial-In Number: +1 855.859.2056
Replay International Dial-In Number: +1 404.537.3406
Passcode: 43465144

About Horizon Pharma plc
Horizon Pharma plc is a biopharmaceutical company focused on improving patients’ lives by identifying, developing, acquiring and commercializing differentiated and accessible medicines that address unmet medical needs.  The Company markets nine medicines through its orphan, rheumatology and primary care business units.  For more information, please visit www.horizonpharma.com.  Follow @HZNPplc on Twitter or view careers on our LinkedIn page.

Note Regarding Use of Non-GAAP Financial Measures
EBITDA, or earnings before interest, taxes, depreciation and amortization, and adjusted EBITDA are used and provided by Horizon as non-GAAP financial measures.  Horizon provides certain other financial measures such as non-GAAP net income, non-GAAP earnings per share, non-GAAP gross profit and gross profit ratio, non-GAAP operating and other expenses, non-GAAP cash from operations and non-GAAP income tax information, each of which include adjustments to GAAP figures.  Adjusted EBITDA, non-GAAP net income and non-GAAP cash from operations are intended to provide additional information on Horizon’s performance, operations, profitability and cash flows.  Adjustments to Horizon’s GAAP figures as well as EBITDA exclude acquisition-related expenses, an upfront fee for a license of a patent, loss on debt extinguishment and loss on sale of long-term investments, as well as non-cash items such as share-based compensation, depreciation and amortization, royalty accretion, non-cash interest expense, and other non-cash adjustments.  Certain other special items or substantive events may also be included in the non-GAAP adjustments periodically when their magnitude is significant within the periods incurred.  Horizon maintains an established non-GAAP cost policy that guides the determination of what costs will be excluded in non-GAAP measures.  Horizon believes that these non-GAAP financial measures, when considered together with the GAAP figures, can enhance an overall understanding of Horizon’s financial and operating performance.  The non-GAAP financial measures are included with the intent of providing investors with a more complete understanding of the Company’s historical and expected 2016 financial results and trends and to facilitate comparisons between periods and with respect to projected information.  In addition, these non-GAAP financial measures are among the indicators Horizon’s management uses for planning and forecasting purposes and measuring the Company’s performance.  For example, adjusted EBITDA is used by Horizon as one measure of management performance under certain incentive compensation arrangements.  These non-GAAP financial measures should be considered in addition to, and not as a substitute for, or superior to, financial measures calculated in accordance with GAAP.  The non-GAAP financial measures used by the Company may be calculated differently from, and therefore may not be comparable to, non-GAAP financial measures used by other companies.  Horizon has not provided reconciliations of its full-year 2016 adjusted EBITDA or non-GAAP income tax outlook to an expected net income (loss) or GAAP income tax expense outlook because certain items such as acquisition-related expenses and share-based compensation that are a component of net income (loss) and impact GAAP income taxes expenses, cannot be reasonably projected due to the significant impact of changes in Horizon’s stock price, the variability associated with the size or timing of acquisitions, and other factors.  These components of net income (loss) could significantly impact Horizon’s actual net income (loss) and income tax expense.  

Forward-Looking Statements
This press release contains forward-looking statements, including, but not limited to, statements related to Horizon Pharma’s expected full-year 2016 net sales and adjusted EBITDA guidance and second-half and full-year 2016 non-GAAP tax rates, expected financial performance in future periods, expected timing of clinical, regulatory and commercial events, Horizon Pharma’s plans to continue discussions with PBMs and payers to expand access to its primary care medicines and the potential outcome of those discussions, the expectation that DUEXIS and VIMOVO will be removed from the CVS/Caremark exclusion list and the timing thereof, expected timing and potential benefits of acquiring the worldwide rights to interferon gamma-1b, potential market opportunity for ACTIMMUNE in FA, potential growth of Horizon Pharma’s business and other statements that are not historical facts.  These forward-looking statements are based on Horizon Pharma’s current expectations and inherently involve significant risks and uncertainties.  Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks that Horizon’s actual full-year 2016 financial and operating results and non-GAAP tax rates may differ from its expectations; Horizon Pharma’s ability to grow net sales from existing products; the availability of coverage and adequate reimbursement and pricing from government and third-party payers and risks relating to the success and costs of Horizon’s patient support program; whether Horizon Pharma is unable to enter into additional business arrangements with pharmacy benefit managers and payers on favorable terms or at all; whether CVS/Caremark makes other changes to its exclusion list or that DUEXIS or VIMOVO are later re-included in the CVS/Caremark exclusion list; risks associated with clinical development and regulatory approvals; risks in the ability to recruit, train and retain qualified personnel; competition, including potential generic competition; the ability to satisfy closing conditions related to Horizon Pharma’s acquisition of the worldwide rights to interferon gamma-1b; the ability to protect intellectual property and defend patents; regulatory obligations and oversight, including any changes in the legal and regulatory environment in which Horizon Pharma operates and those risks detailed from time-to-time under the caption “Risk Factors” and elsewhere in Horizon Pharma’s filings and reports with the SEC.  Horizon Pharma undertakes no duty or obligation to update any forward-looking statements contained in this presentation as a result of new information.

 
Horizon Pharma plc
Consolidated Statements of Operations (Unaudited)
(in thousands, except share and per share data)
                         
            Three Months Ended June 30,   Six Months Ended June 30,
              2016       2015       2016       2015  
                     
  Net sales       $   257,378     $   172,821     $   462,068     $   285,962  
  Cost of goods sold         81,126         61,826         158,359         90,679  
  Gross profit           176,252         110,995         303,709         195,283  
                         
  OPERATING EXPENSES:                  
  Research and development         11,210         8,922         23,932         15,103  
  Sales and marketing         79,589         58,056         155,133         105,119  
  General and administrative         53,986         77,190         120,381         103,470  
  Total operating expenses       144,785         144,168         299,446         223,692  
  Operating income (loss)         31,467         (33,173 )       4,263         (28,409 )
                         
  OTHER EXPENSE, NET:                  
  Interest expense, net         (19,228 )       (19,448 )       (38,686 )       (29,480 )
  Foreign exchange gain (loss)         15         (87 )       (158 )       (924 )
  Loss on induced conversion of debt and debt extinguishment       –          (67,080 )       –          (77,624 )
  Other expense, net         (26 )       (9,078 )       (40 )       (10,069 )
  Total other expense, net       (19,239 )       (95,693 )       (38,884 )       (118,097 )
                         
  Income (loss) before benefit for income taxes       12,228         (128,866 )       (34,621 )       (146,506 )
  BENEFIT FOR INCOME TAXES         (2,756 )       (160,680 )       (4,199 )       (158,767 )
  NET INCOME (LOSS)     $   14,984     $   31,814     $   (30,422 )   $   12,261  
                         
  Net income (loss) per ordinary share – basic         $   0.09     $   0.21     $   (0.19 )   $   0.09  
                         
  Weighted average ordinary shares outstanding – basic       160,468,146         150,771,902         160,186,270         138,369,537  
                         
  Net income (loss) per ordinary share – diluted         $   0.09     $   0.20     $   (0.19 )   $   0.08  
                         
  Weighted average ordinary shares outstanding – diluted       163,920,581         159,797,319         160,186,270         145,031,882  

Horizon Pharma plc
Consolidated Balance Sheets (Unaudited)
(in thousands, except share data)
                   
              As of
              June 30,
2016		   December 31,
2015
  ASSETS    
  CURRENT ASSETS:        
    Cash and cash equivalents   $   424,525     $   859,616  
    Restricted cash       3,169         1,860  
    Accounts receivable, net       304,382         210,437  
    Inventories, net       172,102         18,376  
    Prepaid expenses and other current assets       33,866         15,858  
        Total current assets       938,044         1,106,147  
  Property and equipment, net       21,971         14,020  
  Developed technology, net       1,927,713         1,609,049  
  In-process research and development       66,000         66,000  
  Other intangible assets, net       6,655         7,061  
  Goodwill         255,927         253,811  
  Deferred tax assets, net       4,992         2,278  
  Other assets       6,156         222  
  TOTAL ASSETS   $   3,227,458     $   3,058,588  
                   
  LIABILITIES AND SHAREHOLDERS’ EQUITY        
  CURRENT LIABILITIES:        
    Long-term debt—current portion   $   4,000     $   4,000  
    Accounts payable       58,970         16,590  
    Accrued expenses       75,709         100,046  
    Accrued trade discounts and rebates       220,674         183,769  
    Accrued royalties—current portion       58,008         51,700  
    Deferred revenues—current portion       1,448         1,447  
        Total current liabilities       418,809         357,552  
                   
  LONG-TERM LIABILITIES:        
    Exchangeable notes, net       290,310         282,889  
    Long-term debt, net, net of current       849,377         849,867  
    Accrued royalties, net of current       170,160         123,519  
    Deferred revenues, net of current       8,366         8,785  
    Deferred tax liabilities, net       131,587         113,400  
    Other long-term liabilities       20,636         9,431  
        Total long-term liabilities       1,470,436         1,387,891  
                   
  COMMITMENTS AND CONTINGENCIES        
  SHAREHOLDERS’ EQUITY:        
    Ordinary shares, $0.0001 nominal value; 300,000,000 shares authorized;        
      161,126,363 and 160,069,067 issued at June 30, 2016 and December 31, 2015,        
      respectively, and 160,741,997 and 159,684,701 outstanding at June 30, 2016 and        
      December 31, 2015, respectively.       16         16  
    Treasury stock, 384,366 ordinary shares at June 30, 2016 and December 31, 2015       (4,585 )       (4,585 )
    Additional paid-in capital       2,057,128         2,001,552  
    Accumulated other comprehensive loss       (2,737 )       (2,651 )
    Accumulated deficit       (711,609 )       (681,187 )
        Total shareholders’ equity       1,338,213         1,313,145  
  TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY   $   3,227,458     $   3,058,588  

     

  Horizon Pharma plc
  Consolidated Statements of Cash Flows (Unaudited)
  (in thousands)
                     
            Three Months Ended June 30,   Six Months Ended June 30,
              2016       2015       2016       2015  
             (Unaudited)    (Unaudited)
  CASH FLOWS FROM OPERATING ACTIVITIES:                
  Net income (loss)   $   14,984     $   31,814     $   (30,422 )   $   12,261  
  Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities                
  Depreciation and amortization expense       51,883         32,408         102,525         50,743  
  Equity-settled share-based compensation       27,673         24,665         55,418         31,339  
  Royalty accretion       9,669         3,977         19,028         7,021  
  Royalty liability remeasurement       –          14,277         –          14,277  
  Loss on induced conversions of debt and debt extinguishment       –          16,733         –          21,581  
  Amortization of debt discount and deferred financing costs       4,507         5,622         8,932         7,828  
  Foreign exchange (gain) loss and other adjustments       (14 )       84         159         1,023  
  Changes in operating assets and liabilities:                
  Accounts receivable      (14,094 )       (43,724 )       (83,932 )       (97,167 )
  Inventories       6,460         7,467         13,777         10,555  
  Prepaid expenses and other current assets      (16,384 )       38,904         (16,626 )       4,597  
  Accounts payable      (10,578 )       1,622         42,278         1,604  
  Accrued trade discounts and rebates       (5,121 )       45,408         35,480         47,596  
  Accrued expenses and accrued royalties      (20,006 )       22,514         (43,527 )       16,492  
  Deferred revenues       80         2,804         (418 )       2,778  
  Deferred income taxes       (2,705 )       (160,229 )       (5,362 )       (158,873 )
  Payment of original issue discount upon repayment of 2014 Term Loan Facility       –          (3,000 )       –          (3,000 )
  Other non-current assets and liabilities       949         238         4,174         190  
  Net cash provided by (used in) operating activities       47,303         41,584         101,484         (29,155 )
  CASH FLOWS FROM INVESTING ACTIVITIES:                
  Payments for acquisitions, net of cash acquired       (5,591 )      (1,022,361 )      (520,405 )      (1,022,361 )
  Proceeds from liquidation of available-for-sale investments       –          64,623         –          64,623  
  Change in restricted cash       (391 )       –          (1,309 )       138  
  Purchases of property and equipment       (5,251 )       (704 )       (12,776 )       (2,281 )
  Net cash used in investing activities       (11,233 )       (958,442 )       (534,490 )       (959,881 )
  CASH FLOWS FROM FINANCING ACTIVITIES:                      
  Net proceeds from the issuance of Exchangable Senior Notes       –          (819 )       –          387,181  
  Net proceeds from the issuance of 2023 Senior Notes       –          462,340         –          462,340  
  Net proceeds from the 2015 Term Loan Facility       –          391,719         –          391,719  
  Repayment of the 2015 Term Loan Facility       (1,000 )       –          (2,000 )       –   
  Repayment of the 2014 Term Loan Facility       –          (297,000 )       –          (297,000 )
  Net proceeds from the issuance of ordinary shares       –          475,627         –          475,627  
  Proceeds from the issuance of ordinary shares in connection with warrant exercises       –          4,769         –          14,693  
  Proceeds from the issuance of ordinary shares through ESPP programs       3,235         1,541         3,235         1,541  
  Proceeds from the issuance of ordinary shares in connection with stock option exercises       739         2,099         1,658         3,888  
  Payment of employee withholding taxes relating to share-based awards       (549 )       (741 )       (4,734 )       (1,956 )
  Net cash provided by (used in) financing activities       2,425         1,039,535         (1,841 )       1,438,033  
                         
  Effect of foreign exchange rate changes on cash and cash equivalents       177         169         (244 )       (747 )
                         
  NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS       38,672         122,846         (435,091 )       448,250  
  CASH AND CASH EQUIVALENTS, beginning of the period       385,853         544,211         859,616         218,807  
  CASH AND CASH EQUIVALENTS, end of the period   $   424,525     $   667,057     $   424,525     $   667,057  

         

  Horizon Pharma plc  
  GAAP to Non-GAAP Reconciliations  
  Net Income and Earnings Per Share – Prior Methodology (Unaudited)  
  (in thousands, except share and per share data)  
                           
            Three Months Ended June 30,   Six Months Ended June 30,  
              2016       2015       2016       2015    
                       
                           
  GAAP Net Income (Loss)
   $   14,984     $   31,814     $   (30,422 )   $   12,261    
  Non-GAAP Adjustments:                  
    Remeasurement of royalties for medicines acquired through business combinations       –          14,277         –          14,277    
    Acquisition-related costs       281         46,689         11,297         50,343    
    Upfront fee for license of global patent       –          –          2,000         –     
    Loss on induced conversion of debt and debt extinguishment       –          67,080         –          77,624    
    Amortization and accretion:                  
    Intangible amortization expense       50,792         31,832         100,442         49,510    
    Amortization of debt discount and deferred financing costs       4,507         5,622         8,932         7,848    
    Accretion of royalty liabilities       9,669         3,977         19,028         7,020    
    Amortizaton of inventory step-up adjustment       9,102         3,341         16,548         6,495    
    Share-based compensation       27,997         24,665         55,609         31,339    
    Depreciation expense       1,091         576         2,083         1,230    
    Royalties for medicines acquired through business combinations (1)       (9,095 )       (6,840 )       (17,595 )       (12,036 )  
    Total of pre-tax non-GAAP adjustments       94,344         191,219         198,344         233,650    
    Income tax adjustments – prior methodology       (8,213 )       (56,002 )       (11,365 )       (54,373 )  
    Other non-GAAP income tax adjustments       –          (105,133 )       –          (105,133 )  
    Total of non-GAAP adjustments       86,131         30,084         186,979         74,144    
  Non-GAAP Net Income – Prior Methodology
     $   101,115     $   61,898     $   156,557     $   86,405    
                           
                           
  Non-GAAP Earnings Per Share:                      
                           
    Weighted average shares – Basic           160,468,146         150,771,902         160,186,270         138,369,537    
                           
    Non-GAAP earnings per share – Basic                      
    GAAP loss per share – Basic     $   0.09     $   0.21     $   (0.19 )   $   0.09    
    Non-GAAP adjustments         0.54         0.20         1.17         0.53    
    Non-GAAP earnings per share – Basic – Prior Methodology     $   0.63     $   0.41     $   0.98     $   0.62    
                           
                           
    Weighted average shares – Diluted                    
    Weighted average shares – Basic         160,468,146         150,771,902         160,186,270         138,369,537    
    Ordinary share equivalents         3,452,435         9,025,417         3,630,429         6,662,345    
    Weighted average shares – Diluted         163,920,581         159,797,319         163,816,699         145,031,882    
                           
                           
    Non-GAAP earnings per share – Diluted                    
    GAAP loss per share – Diluted     $   0.09     $   0.20     $   (0.19 )   $   0.08    
    Non-GAAP adjustments         0.53         0.19         1.17         0.52    
    Diluted earnings per share effect of ordinary share equivalents         –          –          (0.02 )       –     
    Non-GAAP earnings per share – Diluted – Prior Methodology     $   0.62     $   0.39     $   0.96     $   0.60    
                           
    (1) Royalties for medicines acquired through business combinations relate to ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, RAVICTI and VIMOVO.    

Horizon Pharma plc  
GAAP to Non-GAAP Reconciliations  
Net Income and Earnings Per Share – New Methodology (Unaudited)  
(in thousands, except share and per share data)  
                         
          Three Months Ended June 30,   Six Months Ended June 30,  
            2016       2015       2016       2015    
                     
                         
  GAAP Net Income (Loss)   $   14,984     $   31,814     $   (30,422 )   $   12,261    
  Non-GAAP Adjustments:                  
  Remeasurement of royalties for medicines acquired through business combinations       –          14,277         –          14,277    
  Acquisition-related costs       281         46,689         11,297         50,343    
  Upfront fee for license of global patent       –          –          2,000         –     
  Loss on induced conversion of debt and debt extinguishment       –          67,080         –          77,624    
  Amortization and accretion:                  
  Intangible amortization expense       50,792         31,832         100,442         49,510    
  Amortization of debt discount and deferred financing costs       4,507         5,622         8,932         7,848    
  Accretion of royalty liabilities       9,669         3,977         19,028         7,020    
  Amortizaton of inventory step-up adjustment       9,102         3,341         16,548         6,495    
  Share-based compensation       27,997         24,665         55,609         31,339    
  Depreciation expense       1,091         576         2,083         1,230    
  Royalties for medicines acquired through business combinations (1)       (9,095 )       (6,840 )       (17,595 )       (12,036 )  
  Total of pre-tax non-GAAP adjustments       94,344         191,219         198,344         233,650    
  Income tax effect of pre-tax non-GAAP adjustments       (18,064 )       (59,028 )       (35,338 )       (59,200 )  
  Other non-GAAP income tax adjustments       –          (105,133 )       –          (105,133 )  
  Total of non-GAAP adjustments       76,280         27,058         163,006         69,317    
  Non-GAAP Net Income       $   91,264     $   58,872     $   132,584     $   81,578    
                         
                         
  Non-GAAP Earnings Per Share:                      
                         
  Weighted average shares – Basic           160,468,146         150,771,902         160,186,270         138,369,537    
                         
  Non-GAAP Earnings Per Share – Basic:                      
  GAAP earnings (loss) per share – Basic     $   0.09     $   0.21     $   (0.19 )   $   0.09    
  Non-GAAP adjustments         0.48         0.18         1.02         0.50    
  Non-GAAP earnings per share – Basic     $   0.57     $   0.39     $   0.83     $   0.59    
                         
                         
  Weighted average shares – Diluted                    
  Weighted average shares – Basic         160,468,146         150,771,902         160,186,270         138,369,537    
  Ordinary share equivalents         3,452,435         9,025,417         3,630,429         6,662,345    
  Weighted average shares – Diluted         163,920,581         159,797,319         163,816,699         145,031,882    
                         
                         
  Non-GAAP Earnings Per Share – Diluted                    
  GAAP earnings (loss) per share – Diluted     $   0.09     $   0.20     $   (0.19 )   $   0.08    
  Non-GAAP adjustments         0.47         0.17         1.02         0.48    
  Diluted earnings per share effect of ordinary share equivalents         –          –          (0.02 )       –     
  Non-GAAP earnings per share – Diluted     $   0.56     $   0.37     $   0.81     $   0.56    
                         
  (1) Royalties for medicines acquired through business combinations relate to ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, RAVICTI and VIMOVO.    

Horizon Pharma plc  
GAAP to Non-GAAP Reconciliations  
EBITDA, Gross Profit and Operating Cash Flow (Unaudited)  
(in thousands, except percentages)  
                         
          Three Months Ended June 30,   Six Months Ended June 30,  
            2016       2015       2016       2015    
                     
EBITDA and Non-GAAP EBITDA:                  
  GAAP Net Income (Loss)       $   14,984     $   31,814     $   (30,422 )   $   12,261    
  Depreciation           1,091         576         2,083         1,230    
  Amortization and accretion:                  
  Intangible amortization expense       50,792         31,832         100,442         49,510    
  Accretion of royalty liabilities         9,669         3,977         19,028         7,020    
  Amortization of deferred revenue         (213 )       (129 )       (419 )       (263 )  
  Amortizaton of inventory step-up adjustment         9,102         3,341         16,548         6,495    
  Interest expense, net (including amortization of                      
  debt discount and deferred financing costs)         19,228         19,448         38,686         29,480    
  Benefit for income taxes           (2,756 )       (160,680 )       (4,199 )       (158,767 )  
  EBITDA       $   101,897     $   (69,821 )   $   141,747     $   (53,034 )  
  Non-GAAP adjustments:                      
  Remeasurement of royalties for medicines acquired through business combinations       –          14,277         –          14,277    
  Acquisition-related costs         281         46,689         11,297         50,343    
  Upfront fee for license of global patent         –          –          2,000         –     
  Loss on induced conversion of debt and debt extinguishment         –          67,080         –          77,624    
  Share-based compensation         27,997         24,665         55,609         31,339    
  Royalties for medicines acquired through business combinations (1)       (9,095 )       (6,840 )       (17,595 )       (12,036 )  
  Total of Non-GAAP adjustments         19,183         145,871         51,311       161,547    
  Adjusted EBITDA     $ 121,080     $ 76,050     $ 193,058     $ 108,513    
                         
Non-GAAP Gross Profit:                    
  GAAP gross profit     $   176,252     $   110,995     $   303,709     $   195,283    
  Non-GAAP gross profit adjustments:                    
  Acquisition-related costs         296         –          411         –     
  Remeasurement of royalties for medicines acquired through business combinations         –          14,277         –          14,277    
  Intangible amortization expense (COGS only)       50,590       31,628       100,037         49,105    
  Accretion of royalty liabilities         9,669         3,977         19,028         7,020    
  Amortizaton of inventory step-up adjustment         9,102         3,341         16,548         6,495    
  Depreciation (COGS only)         100         74         220         203    
  Royalties for medicines acquired through business combinations (1)         (9,095 )       (6,840 )     (17,595 )       (12,036 )  
  Total of Non-GAAP adjustments       60,662       46,457       118,649         65,064    
  Non-GAAP gross profit     $ 236,914     $ 157,452     $ 422,358     $ 260,347    
                         
  GAAP gross profit %       68.5 %     64.2 %     65.7 %     68.3 %  
  Non-GAAP gross profit %       92.0 %     91.1 %     91.4 %     91.0 %  
                         
                         
  GAAP cash provided by (used in) operating activities       $ 47,303     $ 41,584     $ 101,484     $ (29,155 )  
  Cash payments for acquisition-related costs           10,883         34,868         22,577         36,688    
  Cash payments for upfront fee for license of global patent           –          –          2,000         –     
  Cash payments for induced debt conversion           –          4,776         –          10,472    
  Cash payment for debt extinguishment           –          45,367         –          45,367    
  Payment of original issue discount on debt extinguishment           –          3,000         –          3,000    
  Non-GAAP operating cash flow       $   58,186     $   129,595     $   126,061     $   66,372    
                         
 (1) Royalties for medicines acquired through business combinations relate to ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, RAVICTI and VIMOVO.    

      Horizon Pharma plc
      Certain Income Statement Line Items – Non-GAAP Adjusted
      For the Three Months Ended June 30, 2016
      (Unaudited)
                     
                     
                 Income Tax  
         Research &  Sales &  General &   Interest  Benefit  
       COGS  Development  Marketing  Administrative  Expense  (Expense)  
                     
GAAP as reported $   (81,126 ) $   (11,210 ) $   (79,589 ) $   (53,986 ) $   (19,228 ) $   2,756      
                     
Non-GAAP Adjustments (in thousands):                
  Acquisition-related costs(1)     297       506       –        (522 )     –        –       
  Upfront fee for license of global patent(2)     –        –        –        –        –        –       
  Amortization and accretion:                
    Intangible amortization expense(3)     50,589       –        203       –        –        –       
    Amortization of debt discount and deferred financing costs(4)     –        –        –        –        4,507       –       
    Accretion of royalty liability(5)     9,669       –        –        –        –        –       
    Amortization of inventory step-up adjustment(6)     9,102       –        –        –        –        –       
  Share-based compensation(7)     –        2,238       6,932       18,827       –        –       
  Depreciation expense(8)     100       –        15       976       –        –       
  Royalties for medicines acquired through business combinations(9)     (9,095 )     –        –        –        –        –       
  Income tax effect on pre-tax non-GAAP adjustments(10)     –        –        –        –        –        (18,064 )    
    Total of non-GAAP adjustments     60,662       2,744       7,150       19,281       4,507       (18,064 )    
                     
Non-GAAP $ (20,464 ) $ (8,466 ) $ (72,439 ) $ (34,705 ) $ (14,721 ) $   (15,308 )    
                     
      Horizon Pharma plc
      Certain Income Statement Line Items – Non-GAAP Adjusted
      For the Three Months Ended June 30, 2015
      (Unaudited)
                     
                 Loss on Induced    
                  Debt Conversion    Income Tax
         Research &  Sales &  General &   Interest   & Debt     Benefit
       COGS  Development  Marketing  Administrative  Expense  Extinguishment  Other  (Expense)
                     
GAAP as reported $   (61,826 ) $   (8,922 ) $   (58,056 ) $   (77,190 ) $   (19,448 ) $   (67,080 ) $   (9,078 ) $   160,680  
                     
Non-GAAP Adjustments (in thousands):                
  Loss on induced conversion of debt and debt extinguishment(11)     –        –        –        –        –        67,080       –        –   
  Acquisition-related costs(1)     –        –        –        37,689       –        –        9,000       –   
  Amortization and accretion:                
    Intangible amortization expense(3)     31,628       –        204       –        –        –        –        –   
    Amortization of debt discount and deferred financing costs(4)     –        –        –        –        5,622       –        –         –   
    Accretion of royalty liability(5)     3,977       –        –        –        –        –        –        –   
    Amortization of inventory step-up adjustment(6)     3,341       –        –        –        –        –        –        –   
  Remeasurement of royalties for products acquired through business combinations(12)     14,277       –        –        –        –        –        –        –   
  Share-based compensation(7)     –        2,212       5,735       16,718       –        –        –        –   
  Depreciation expense(8)     74       –        –        502       –        –        –        –   
  Royalties for medicines acquired through business combinations(9)     (6,840 )     –        –        –        –        –        –        –   
  Income tax effect on pre-tax non-GAAP adjustments(10)     –        –        –        –        –        –        –        (59,028 )
  Other non-GAAP income tax adjustments(13)     –        –        –        –        –        –        –        (105,133 )
    Total of non-GAAP adjustments     46,457       2,212       5,939       54,909       5,622       67,080       9,000       (164,161 )
                     
Non-GAAP $ (15,369 ) $ (6,710 ) $ (52,117 ) $ (22,281 ) $ (13,826 ) $   –    $   (78 ) $   (3,481 )

      Horizon Pharma plc
      Certain Income Statement Line Items – Non-GAAP Adjusted
      For the Six Months Ended June 30, 2016
      (Unaudited)
                     
                     
                 Income Tax  
         Research &  Sales &  General &   Interest  Benefit  
       COGS  Development  Marketing  Administrative  Expense  (Expense)  
                     
GAAP as reported $   (158,359 ) $   (23,932 ) $   (155,133 ) $   (120,381 ) $   (38,686 ) $   4,199      
                     
Non-GAAP Adjustments (in thousands):                
  Acquisition-related costs(1)     411       538       –        10,348       –        –       
  Upfront fee for license of global patent(2)     –        2,000       –        –        –        –       
  Amortization and accretion:                
    Intangible amortization expense(3)     100,037       –        405       –        –        –       
    Amortization of debt discount and deferred financing costs(4)     –        –        –        –        8,932       –       
    Accretion of royalty liability(5)     19,028       –        –        –        –        –       
    Amortization of inventory step-up adjustment(6)     16,548       –        –        –        –        –       
  Share-based compensation(7)     –        4,363       12,610       38,636       –        –       
  Depreciation expense(8)     220       –        26       1,837       –        –       
  Royalties for medicines acquired through business combinations(9)     (17,595 )     –        –        –        –        –       
  Income tax effect on pre-tax non-GAAP adjustments(10)     –        –        –        –        –        (35,338 )    
    Total of non-GAAP adjustments     118,649       6,901       13,041       50,821       8,932       (35,338 )    
                     
Non-GAAP $ (39,710 ) $ (17,031 ) $ (142,092 ) $ (69,560 ) $ (29,754 ) $   (31,139 )    
                     
      Horizon Pharma plc
      Certain Income Statement Line Items – Non-GAAP Adjusted
      For the Six Months Ended June 30, 2015
      (Unaudited)
                     
                 Loss on Induced    
                  Debt Conversion    Income Tax
         Research &  Sales &  General &   Interest   & Debt     Benefit
       COGS  Development  Marketing  Administrative  Expense  Extinguishment  Other  (Expense)
                     
GAAP as reported $   (90,679 ) $   (15,103 ) $   (105,119 ) $   (103,470 ) $   (29,480 ) $   (77,624 ) $   (10,069 ) $   158,767  
                     
Non-GAAP Adjustments (in thousands):                
  Loss on induced conversion of debt and debt extinguishment(11)     –        –        –        –        –        77,624       –        –   
  Acquisition-related costs(1)   23     94       –      40,226       –        –      10,000       –   
  Amortization and accretion:                
    Intangible amortization expense(3)     49,104       –        406       –        –        –        –        –   
    Amortization of debt discount and deferred financing costs(4)     –        –        –        –        7,848       –        –        –   
    Accretion of royalty liability(5)     7,020       –        –        –        –        –        –        –   
    Amortization of inventory step-up adjustment(6)     6,495       –        –        –        –        –        –        –   
  Remeasurement of royalties for products acquired through business combinations(12)     14,277       –        –        –        –        –        –        –   
  Share-based compensation(7)     –        2,670       8,536       20,133       –        –        –        –   
  Depreciation expense(8)     203       –        –        1,027       –        –        –        –   
  Royalties for medicines acquired through business combinations(9)     (12,036 )     –        –        –        –        –        –        –   
  Income tax effect on pre-tax non-GAAP adjustments(10)     –        –        –        –        –        –        –      (59,200 )
  Other non-GAAP income tax adjustments(13)     –        –        –        –        –        –      –      (105,133 )
    Total of non-GAAP adjustments     65,086       2,764       8,942       61,386       7,848       77,624     10,000     (164,333 )
                     
Non-GAAP $ (25,593 ) $ (12,339 ) $ (96,177 ) $ (42,084 ) $ (21,632 ) $   –    $   (69 ) $   (5,566 )
                                                 

NOTES FOR CERTAIN INCOME STATEMENT LINE ITEMS – NON-GAAP ADJUSTED 
(in thousands)

(1) Expenses, including legal and consulting fees, incurred in connection with the Company’s acquisitions of Vidara Therapeutics International Public Limited Company (“Vidara”), Hyperion Therapeutics, Inc. (“Hyperion”) and Crealta Holdings LLC (“Crealta”), its agreement to acquire the worldwide rights to interferon gamma-1b, and its withdrawn offer to acquire Depomed Inc. have been excluded.

(2) Represents an upfront fee paid for a license of a global patent.

(3) Intangible amortization expenses are associated with the Company’s intellectual property rights, developed technology and customer relationships of VIMOVO, LODOTRA®, RAYOS, ACTIMMUNE, PENNSAID 2%, RAVICTI, BUPHENYL, KRYSTEXXA and MIGERGOT®.

(4) Represents amortization of debt discount and deferred financing costs associated with the Company’s debt.

(5) Represents accretion expense associated with the ACTIMMUNE, VIMOVO, RAVICTI, BUPHENYL, KRYSTEXXA and MIGERGOT royalties for the three and six months ended June 30, 2016 and represents accretion expense associated with the ACTIMMUNE, VIMOVO, RAVICTI and BUPHENYL royalties for the three and six months ended June 30, 2015.

(6) In connection with the Crealta acquisition, the KRYSTEXXA and MIGERGOT inventory was stepped up in value by $161,901 and during the three months ended June 30, 2016, the Company recognized in cost of goods sold $9,102 of step-up inventory costs related to KRYSTEXXA and MIGERGOT inventory sold.  During the six months ended June 30, 2016, the Company recognized in cost of goods sold $16,548 of step-up inventory costs related to KRYSTEXXA and MIGERGOT inventory sold.  In connection with the Hyperion acquisition, the RAVICTI and BUPHENYL inventory was stepped up in value by $8,682 and during the second quarter of 2015, the Company recognized in cost of goods sold $3,341 of step-up inventory costs related to RAVICTI and BUPHENYL.  In connection with the Vidara acquisition, the ACTIMMUNE inventory was stepped up in value by $14,218 and during the six months ended June 30, 2015, the Company recognized in cost of goods sold $3,154 of step-up inventory costs related to ACTIMMUNE.

(7) Represents share-based compensation expense associated with the Company’s stock option, restricted stock unit, and performance stock unit grants to its employees and non-employees, its cash-settled long-term incentive program and its employee stock purchase plan.

(8) Represents depreciation expense related to the Company’s property, equipment, software and leasehold improvements.

(9) Royalties of $9,095 and $17,595 were incurred during the three and six months ended June 30, 2016, respectively, based on the periods’ net sales for VIMOVO, ACTIMMUNE, RAVICTI, BUPHENYL, KRYSTEXXA and MIGERGOT.  Royalties of $6,840 and $12,036 were incurred during the three and six months ended June 30, 2015, respectively, based on the periods’ net sales for VIMOVO, ACTIMMUNE, RAVICTI and BUPHENYL.

(10) Income tax adjustments on pre-tax non-GAAP adjustments represent the estimated income tax impact of each pre-tax non-GAAP adjustment based on the statutory income tax rate of the applicable jurisdictions for each non-GAAP adjustment.

(11) During the three months ended June 30, 2015, the Company recorded a loss on induced debt conversions of $67,080, which represented an early redemption payment of $45,366, the write-down of $16,733 in debt discount and deferred financing costs, $4,635 in additional exchange consideration to debt holders and $346 in expenses incurred in connection with the induced debt conversions.  During the six months ended June 30, 2015, the Company recorded a loss on induced debt conversions of $77,624, which represented an early redemption payment of $45,366, the write-down of $21,581 in debt discount and deferred financing costs, $10,005 in additional exchange consideration to debt holders and $672 in expenses incurred in connection with the induced debt conversions.

(12) At the time of the Company’s acquisition of the rights to ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, RAVICTI and VIMOVO, the Company estimated the fair value of contingent royalties payable to third parties using an income approach under the discounted cash flow method, which included revenue projections and other assumptions the Company made to determine the fair value.  If the Company significantly over performs or underperforms against its original revenue projections or it becomes necessary to make changes to assumptions as a result of a triggering event, the Company is required to reassess the fair value of the contingent royalties payable.  Any subsequent adjustment to fair value is recorded in the period such adjustment is made as either an increase or decrease to royalties payable, with a corresponding increase or decrease in cost of goods sold, in accordance with established accounting policies.  During the second quarter of 2015, the Company recorded a charge of $14,277 to cost of goods sold to adjust the amount of the contingent royalty liabilities relating to ACTIMMUNE and VIMOVO.

(13) Other non-GAAP income tax adjustments in the three months ended June 30, 2015 of $105,133 related to the release of certain valuation allowances in connection with the Hyperion acquisition.

  Horizon Pharma plc
GAAP to Non-GAAP Tax Rate Reconciliation (Unaudited)
(in millions, except percentages)
   
    Q1 2016     Q1 2015
    Pre-tax Net
Income (Loss)		  Income Tax Expense (Benefit) Tax Rate Net Income (Loss) Diluted Earnings (Loss) Per Share     Pre-tax Net
Income (Loss)		  Income Tax Expense (Benefit) Tax Rate Net Income (Loss) Diluted Earnings (Loss) Per Share
  As reported – GAAP $   (46.8 ) $   (1.4 )   3.1 % $   (45.4 ) $   (0.28 )   As reported – GAAP $   (17.6 ) $   1.9     (10.8 )% $   (19.5 ) $   (0.16 )
  Non-GAAP adjustments     104.0       17.3         86.7       Non-GAAP adjustments     42.4       0.2         42.2    
  Non-GAAP – new methodology $   57.2   $   15.9     27.7 % $   41.3   $   0.25     Non-GAAP – new methodology $   24.8   $   2.1     8.4 % $   22.7   $   0.16  
                           
  As reported – GAAP $   (46.8 ) $   (1.4 )   3.1 % $   (45.4 ) $   (0.28 )   As reported – GAAP $   (17.6 ) $   1.9     (10.8 )% $   (19.5 ) $   (0.16 )
  Non-GAAP adjustments     104.0       3.2         100.8       Non-GAAP adjustments     42.4       (1.6 )       44.0    
  Non-GAAP – prior methodology $ 57.2   $  1.8     3.0 % $ 55.4   $ 0.34     Non-GAAP – prior methodology $   24.8   $   0.3     1.1 % $   24.5   $   0.18  
                           
                           
    Q2 2016     Q2 2015
    Pre-tax Net Income  Income Tax Expense (Benefit) Tax Rate Net Income Diluted Earnings Per Share     Pre-tax Net Income (Loss)  Income Tax Expense (Benefit) Tax Rate Net Income (Loss) Diluted Earnings Per Share
  As reported – GAAP $   12.2   $   (2.8 )   (22.5 )% $   15.0   $   0.09     As reported – GAAP $   (128.9 ) $   (160.7 )   124.7 % $   31.8   $   0.20  
  Non-GAAP adjustments     94.3       18.0         76.3       Non-GAAP adjustments     191.2       59.0         132.2    
  Non-GAAP – new methodology $   106.5   $   15.2     14.4 % $   91.3   $   0.56     Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
                Non-GAAP – new methodology $   62.3   $   3.4     5.6 % $   58.9   $   0.37  
  As reported – GAAP $   12.2   $   (2.8 )   (22.5 )% $   15.0   $   0.09                
  Non-GAAP adjustments     94.3       8.2         86.1       As reported – GAAP $   (128.9 ) $   (160.7 )   124.7 % $   31.8   $   0.20  
  Non-GAAP – prior methodology $   106.5   $   5.4     5.1 % $   101.1   $   0.62     Non-GAAP adjustments     191.2       56.0         135.2    
                Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
                Non-GAAP – prior methodology $   62.3   $   0.4     0.7 % $   61.9   $   0.39  
    Q2 2016 YTD              
    Pre-tax Net Income (Loss)  Income Tax Expense (Benefit) Tax Rate Net Income (Loss) Diluted Earnings (Loss) Per Share              
  As reported – GAAP $   (34.6 ) $   (4.2 )   12.1 % $   (30.4 ) $   (0.19 )     Q2 2015 YTD
  Non-GAAP adjustments     198.3       35.3         163.0         Pre-tax Net Income (Loss)  Income Tax Expense (Benefit) Tax Rate Net Income (Loss) Diluted Earnings Per Share
  Non-GAAP – new methodology $   163.7   $   31.1     19.0 % $   132.6   $   0.81     As reported – GAAP $   (146.5 ) $   (158.8 )   108.4 % $   12.3   $   0.08  
                Non-GAAP adjustments     233.6       59.2         174.4    
  As reported – GAAP $   (34.6 ) $   (4.2 )   12.1 % $   (30.4 ) $   (0.19 )   Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
  Non-GAAP adjustments     198.3       11.4         186.9       Non-GAAP – new methodology $   87.1   $   5.5     6.4 % $   81.6   $   0.56  
  Non-GAAP – prior methodology $   163.7   $   7.2     4.4 % $   156.5   $   0.96                
                As reported – GAAP $   (146.5 ) $   (158.8 )   108.4 % $   12.3   $   0.08  
                Non-GAAP adjustments     233.6       54.4         179.2    
        Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
                Non-GAAP – prior methodology $   87.1   $   0.7     0.8 % $   86.4   $   0.60  
                           
                           
                  Q3 2015
                  Pre-tax Net Income  Income Tax Expense (Benefit) Tax Rate Net Income Diluted Earnings Per Share
                As reported – GAAP $   25.2   $   22.0     87.0 % $   3.2   $   0.02  
                Non-GAAP adjustments     91.6       25.0         66.6    
                Non-GAAP – new methodology $   116.8   $   47.0     40.2 % $   69.8   $   0.42  
                           
                           
        As reported – GAAP $   25.2   $   22.0     87.0 % $   3.2   $   0.02  
                Non-GAAP adjustments     91.6       (22.2 )       113.8    
                Non-GAAP – prior methodology $   116.8   $   (0.2 )   (0.2 )% $   117.0   $   0.70  
                           
                  Q3 2015 YTD
                  Pre-tax Net Income (Loss)  Income Tax Expense (Benefit) Tax Rate Net Income (Loss) Diluted Earnings Per Share
                As reported – GAAP $   (121.3 ) $   (136.8 )   112.8 % $   15.5   $   0.10  
                Non-GAAP adjustments     325.2       84.2         241.0    
                Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
                Non-GAAP – new methodology $   203.9   $   52.5     25.8 % $   151.4   $   0.98  
                           
                As reported – GAAP $   (121.3 ) $   (136.8 )   112.8 % $   15.5   $   0.10  
                Non-GAAP adjustments     325.2       32.2         293.0    
        Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
                Non-GAAP – prior methodology $   203.9   $   0.5     0.3 % $   203.4   $   1.32  
                           
                           
                  Q4 2015
                  Pre-tax Net Income (Loss)  Income Tax Expense (Benefit) Tax Rate Net Income Diluted Earnings Per Share
                As reported – GAAP $   (11.4 ) $   (35.4 )   309.3 % $   24.0   $   0.15  
                Non-GAAP adjustments     119.5       38.0         81.5    
                Non-GAAP – new methodology $   108.1   $   2.6     2.4 % $   105.5   $   0.64  
                           
        As reported – GAAP $   (11.4 ) $   (35.4 )   309.3 % $   24.0   $   0.15  
                Non-GAAP adjustments     119.5       41.1         78.4    
                Non-GAAP – prior methodology $   108.1   $   5.7     5.2 % $   102.4   $   0.63  
                           
                  FY 2015
                  Pre-tax Net Income (Loss)  Income Tax Expense (Benefit) Tax Rate Net Income (Loss) Diluted Earnings Per Share
                As reported – GAAP $   (132.7 ) $   (172.2 )   129.8 % $   39.5   $   0.25  
                Non-GAAP adjustments     444.7       122.2         322.5    
                Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
                Non-GAAP – new methodology $   312.0   $   55.1     17.7 % $   256.9   $   1.65  
                           
                           
                As reported – GAAP $   (132.7 ) $   (172.2 )   129.8 % $   39.5   $   0.25  
                Non-GAAP adjustments     444.7       73.3         371.4    
                Other Non-GAAP tax adjustment     –        105.1         (105.1 )  
        Non-GAAP – prior methodology $   312.0   $   6.2     2.0 % $   305.8   $   1.96  

         

CONTACT: Contacts:

Investors:						  
John Thomas						  
Executive Vice President, Strategy & Investor Relations	  
[email protected]                               

Tina Ventura						  
Vice President, Investor Relations			  
[email protected]

U.S. Media:
Geoff Curtis
Senior Vice President, Corporate Communications 
[email protected]         

Ireland Media:
Ray Gordon
Gordon MRM	
[email protected]