Vertebrate Genomes Project Co-Leader Erich Jarvis will use BioNano to Generate Thousands of Reference Genomes

SAN DIEGO, Oct. 13, 2016 (GLOBE NEWSWIRE) — BioNano Genomics, the leader in physical genome mapping, together with Howard Hughes Medical Institute (HHMI) Investigator and new Rockefeller University Professor, Erich Jarvis, Ph.D., today announced that his team will use BioNano Genomics’ Next Generation Mapping (NGM) combined with Pacific Biosciences sequencing technology to construct thousands of vertebrate reference genomes in the Vertebrate Genomes Project.

Dr. Jarvis’s lab and his collaborator Dr. Olivier Fredrigo, co-director of the Duke University Genome Sequencing Center, performed a systematic evaluation of available DNA sequencing and scaffolding technologies. They concluded that a combination of BioNano’s NGM and PacBio sequencing will yield one of the most well-structured and informative genome assemblies, making the technologies a very good combination for establishing reference quality genomes.

Dr. Jarvis has purchased an Irys® System for next-generation mapping to play an integral role in generating quality reference genomes for the Genome 10K (G10K) and Bird 10,000 Genomes (B10K) projects. The mission of G10K and B10K projects is to generate high-quality references, diploid to multiploid, genomes of vertebrate species. For future sequencing of species, Dr. Jarvis and other members of these projects plan to generate sequence assemblies with the Pacific Biosciences Sequel System and an optical map with BioNano’s Irys® System. Combining both outputs using BioNano’s hybrid scaffolding software yields high-quality reference genomes.

Genomics research over the past 20 years has produced an unprecedented amount of information and has increased our understanding of the molecular basis for evolution and disease. The addition of next-generation Irys® System mapping to the G10K and B10K projects is expected to produce high-quality reference genomes that will allow discovery of structural variations and complete structure of genes that control complex traits and their disorders. Revealing the accurate and complete structure of the thousands of vertebrate genomes will also help researchers understand vertebrate evolution. As such, the project members hope to secure additional Irys® Systems to support an increased rate of sequencing and mapping of vertebrate genomes.

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